- Last Updated on Sunday, 20 November 2016 21:12
PHI and Malmö University have a long-standing collaboration, dating back to 2008. The collaboration has resulted in several peer reviewed publications and a doctoral thesis. In late 2016, the European Commission granted 2.1 million euro to GlycoImaging – a joint cancer research project to develop improved methods for clinically diagnosing cancer.
Current methods for diagnosing cancer primarily focus on the proteins associated with cancer. However, there is increasing evidence that carbohydrates play an important role in the development and progression of malignant cancer. Current methods use and rely on antibodies created by living organisms. These natural antibodies, however, are not sufficiently specific to accurately detect and image carbohydrates.
“Oncology research and diagnostics are in need of low-cost and robust probes to detect carbohydrates. The goal of the GlycoImaging project is to meet this need by combining specific carbohydrate probes – in the form of molecular imprinted polymers or ‘plastic antibodies’ – with holographic microscopy.”
Prof. Anette Gjörloff Wingren
The GlycoImaging project is coordinated by Malmö University and commercialized by PHI. Additional partners are Bundesanstalt für Materialforschung und Prüfung (Germany’s federal technology research institute), Umeå, Copenhagen and Turku University.
Peer reviewed publications
Interfacing antibody-based microarrays and digital holography enables label-free detection for loss of cell volume
Future Science OA 2015
Digital Holographic Microscopy for Non-Invasive Monitoring of Cell Cycle Arrest in L929 Cells
PLOS ONE 2014
Cells and Holograms – Holograms and Digital Holographic Microscopy as a Tool to Study the Morphology of Living Cells
Holography – Basic Principles and Contemporary Applications 2013
Digital Holography and Cell Studies in Holography
Research and Technologies 2011
Digital holographic microscopy – innovative and non-destructive analysis of living cells
Microscopy: Science, Technology, Applications and Education 2010
Faculty of Health and Society, Malmö University
Jan Waldenströms gata 25, AS:F502
205 06 Malmö, Sweden